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This is not the first time that nonprofit organizations and fundraisers have had to adapt to new technologies. Radio, television, newspapers, telephone, fax machine, computers, electronic databases, and direct mail have all affected the way we raise money. Some of the new methods that have evolved are more successful; others have been used with less success. Each new advance in technology has created a particular set of challenges for nonprofits and their donors; each has triggered a corresponding set of fundraising norms. For nonprofit organizations, the Internet provides an unprecedented and cost-effective opportunity to build and enhance relationships with supporters, volunteers, clients, and the communities they serve. Connecting with supporters online provides a new means for converting interest in a mission to direct involvement and support. In March 2001, Harvard s Professor James Austin wrote, . . . make no mistake; the ePhilanthropy revolution is here to stay, and it will transform charitable giving in as profound a way as technology is changing the

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ences were seen between storage in glass vials or PP/glass syringes However, PSI reconstituted with lactated Ringer s injection and lactated Ringer s and 5% dextrose injection showed visual precipitation in many vials as con rmed by HPLC assay values at all points The stability of an ophthalmic solution formulation of unoprostone isopropyl (UI) (a prostaglandin-like compound marketed as Rescula for treatment of elevated intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension) was investigated in two types of packaging materials: PP and low-density polyethylene (LDPE) The concentrations of UI and its degradation products were monitored as a function of time It was found that the rate of disappearance of drug was faster for the formulation stored in LDPE bottles than that stored in PP bottles.

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Further studies indicated that the inferior stability observed with LDPE packaging was primarily due to the sorption of UI to the packaging material and to a lesser degree chemical degradation The sorption was found to be temperature dependent: Lowering the temperature reduced the sorption, thus improving the shelf life of the product [107] The USP has proposed large-globule-size limits to ensure the physical stability of lipid injectable emulsions, expressed as the percent far greater than 5 m, or PFAT5, not exceeding 005% Recent studies showed that injectable emulsions packaged in newly introduced plastic containers exceed the proposed USP PFAT5 limits and subsequently become signi cantly less stable during simulated syringe-based infusion Although modest growth in large-diameter fat globules was observed for the glass-based lipids, they remained within proposed USP globule size limits throughout the study.

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Here s one more paint bucket tip for good measure: You can use the paint bucket to color the empty window area around your image. First, make your image window larger than your image, so you can see some gray canvas area around the image. Now Shift-click with the paint bucket to fill the canvas area with the foreground color. This technique can come in handy if you re creating a presentation or you simply don t care for the default shade of gray.

Thus glass-based lipids seem to be a more stable dosage form and potentially a safer way to deliver via syringe infusion to critically ill neonates [108] Considerable interest has been shown, in recent years, in the clinical use of intravenous nitroglycerin for the treatment of myocardial infarction and in open heart surgery In its intravenous use loss of the drug to PVC bags has been identi ed as a problem and has been characterized as a diffusionally controlled absorption process having a half-life for fractional absorption of 32 h at 30 C [109] Moreover, in recent studies, administration set tubing has been implicated as the source for the observed loss of nitroglycerin from solution [110 112] Quantitative studies have been reported on the loss of nitroglycerin to plastic intravenous tubing.

It was found that in the short time periods the loss of nitroglycerin from normal saline solutions to PVC tubing could be treated as an adsorption process The rate of adsorption was rapid and could be quanti ed as an apparent rst-order process The half-life of the loss was 26 min [113] Recently a model describing the loss of nitroglycerin from the solution in the plastic bags as a rapid adsorption onto the plastic surface followed by partitioning into the plastic was proposed [114] The mechanism of loss of nitroglycerin stored in plastic and glass containers was studied from an equilibrium and kinetic approach Data showed that nitroglycerin was removed from aqueous solution by the plastic container material through an absorption process Nitroglycerin loss from aqueous solution did not occur by hydrolysis since solutions stored in glass containers at pH 5.

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